" /> Panobinostat Lactate - CISMeF





Preferred Label : Panobinostat Lactate;

NCIt synonyms : Panobinostat Lactate Anhydrous;

NCIt definition : The lactate form of panobinostat, a pan histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon administration, panobinostat selectively targets, binds to and inhibits HDAC, which induces hyperacetylation of core histone proteins. The accumulation of highly acetylated histones leads to chromatin remodeling, an altered pattern of gene expression, inhibition of tumor oncogene transcription and the selective transcription of tumor suppressor genes. This results in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDAC, upregulated in many tumor cell types, is an enzyme family that deacetylates histone proteins.;

UNII : HN0T99OO4V;

InChIKey : XVDWNSFFSMWXJJ-ASTDGNLGSA-N;

CAS number : 960055-56-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 960055-56-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Farydak;

NCI Metathesaurus CUI : CL1413468;

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Keyword's position in hierarchy(ies) : arborescence

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14/05/2024


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