" /> Panobinostat - CISMeF





Preferred Label : Panobinostat;

NCIt synonyms : (2E)-N-hydroxy-3-(4-(((2-(2-methyl-1h-indol-3-yl)ethyl)amino)methyl)phenyl)prop-2-enamide;

NCIt related terms : LBH589; Faridak;

NCIt definition : A cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.;

Alternative definition : NCI-GLOSS: A drug being studied in the treatment of cancer. It blocks enzymes needed for cells to grow and divide and may kill cancer cells. Panobinostat may also prevent the growth of new blood vessels that tumors need to grow. It is a type of histone deacetylase inhibitor and a type of antiangiogenesis agent.;

UNII : 9647FM7Y3Z;

InChIKey : FPOHNWQLNRZRFC-ZHACJKMWSA-N;

CAS number : 404950-80-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 404950-80-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Faridak;

Molecule name : LBH589;

Chemical formula : C21H23N3O2;

Codes from synonyms : CDR0000637719; CDR0000637718; CDR0000637720; 385;

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12/05/2024


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