Remetinostat - CISMeF

Preferred Label : Remetinostat;

NCIt synonyms : Methyl 4-((8-(Hydroxyamino)-8-Oxooctanoyl)oxy)benzoate; SHAPE; Methylparaben Suberohydroxamic Acid Phenyl Ester;

NCIt definition : A topical formulation containing the histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Upon cutaneous administration, SHP-141 selectively binds to and inhibits HDAC, resulting in an accumulation of highly acetylated histones in the skin (dermis and epidermis), the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. These events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Topical administration of SHP-141 allows for high concentrations of this agent locally while minimizing systemic toxicity.;

UNII : 37NT056AT4;

InChIKey : XDZAHHULFQIBFE-UHFFFAOYSA-N;

CAS number : 946150-57-8;

Molecule name : SHP-141;

NCI Metathesaurus CUI : CL430257;

Details

Origin ID

C97513;

UMLS CUI

C3273461;

Automatic exact mappings (from CISMeF team)
- Formations (qualifier value) [SNOMED CT concept]
- Formed (qualifier value) [SNOMED CT concept]
- Trainers [UNESCO concept]
- Trainers [HPMULTI term]
- Training [HPMULTI term]
- Training [UNESCO concept]
- Training [HPMULTI category]
- Training [ICHI action]
- Training [DeCS]
- education [MeSH Qualifier]
- formed [SNOMED Notion]
- morphologic descriptor [Radlex concept]
- trainer [Q-code]
- training [Q-code]
- training [CISMeF resources Type]
- training [Blood Transfusion thesaurus concept]
- training [ICPS Descriptor]
Currated CISMeF NLP mapping
- remetinostat [MeSH Supplementary Concept]
- remetinostat [MeSH concept]
False automatic mappings
- Shape [LOINC component]
- Shape [LOINC Property]
- Shape [LOINC Property]
- Shape (attribute) [SNOMED CT concept]
- Shape finding (qualifier value) [SNOMED CT concept]
- With shape (attribute) [SNOMED CT concept]
- with shape [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- remetinostat [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients