Preferred Label : Mocetinostat;
NCIt synonyms : Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-; N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide;
NCIt related terms : MGCD0103;
NCIt definition : A rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide
HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits
Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic
changes in tumor cells and so tumor cell death; although the exact mechanism has yet
to be defined, tumor cell death may occur through the induction of apoptosis, differentiation,
cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down
regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression
of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated
with a poor prognosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It blocks enzymes needed for cell division and may kill cancer cells. It is a type
of histone deacetylase (HDAC) inhibitor.;
UNII : A6GWB8T96J;
InChIKey : HRNLUBSXIHFDHP-UHFFFAOYSA-N;
CAS number : 726169-73-9;
Molecule name : MGCD-0103; MG-0103; MGCD 0103;
Chemical formula : C23H20N6O;
Codes from synonyms : CDR0000630923; CDR0000658785; 337;
Origin ID : C62521;
UMLS CUI : C2002471;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
