Preferred Label : Romidepsin;
NCIt synonyms : L-Valine, N-(3-Hydroxy-7-Mercapto-1-Oxo-4-Heptenyl)-D-Valyl-D-Cysteinyl-(Z)-2,3 -Didehydro-2-Aminobutanoyl-,
xi-Lactone, Cyclic (1-2)-Disulfide, (S-(E))-; N-[(3S,4E)-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine,
(4-1) Lactone, Cyclic; Antibiotic FR 901228; L-Valine, N- (3-hydroxy-7-mercapto-1-oxo-4-heptenyl)valyl- cysteinyl-2, 3-didehydro-2-aminobutanoyl-,xi-lactone,
cyclic (1-2)-disulfide;
NCIt related terms : FR901228; N-[(3S,4E)-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine,
(4- 1) Lactone, Cyclic; depsipeptide;
NCIt definition : A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum
with antineoplastic activity. After intracellular activation, romidepsin binds to
and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression
and the induction of cell differentiation, cell cycle arrest, and apoptosis. This
agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein
90 (Hsp90)-dependent oncoproteins.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Romidepsin is a type
of depsipeptide and histone deacetylase inhibitor.;
UNII : CX3T89XQBK;
InChIKey : OHRURASPPZQGQM-GCCNXGTGSA-N;
CAS number : 128517-07-7;
Drug name : Istodax;
Molecule name : FR 901228; FK-228; FR-901228; FK 228;
Chemical formula : C24H36N4O6S2;
NSC code : 630176;
ChEBI ID : CHEBI:61080;
Codes from synonyms : CDR0000046707; 50157; CDR0000509038; CDR0000045521; 451;
Origin ID : C1544;
UMLS CUI : C1527027;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
