Sodium Phenylbutyrate

Preferred Label : Sodium Phenylbutyrate;

NCIt synonyms : Phenylbutyrate Sodium; 4-Phenylbutyric Acid, Sodium Salt; 4-Phenylbutyrate;

NCIt related terms : phenylbutyrate; Sodium 4-phenylbutyrate;

NCIt definition : The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called differentiating agents.;

UNII : NT6K61736T;

InChIKey : VPZRWNZGLKXFOE-UHFFFAOYSA-M;

CAS number : 1716-12-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1716-12-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Buphenyl; SPB11;

Chemical formula : C10H11O2.Na;

NSC code : 657802;

Codes from synonyms : 31743; CDR0000045402; NSC0657802;

Details

Origin ID

C1440;

UMLS CUI

C0718066;

Automatic exact mappings (from CISMeF team)
- 4-phenylbutyrate [MeSH concept]
- 4-phenylbutyric acid [MeSH Supplementary Concept]
- Phenylbutyrate (substance) [SNOMED CT concept]
- Sodium phenylbutyrate [ICD-11 Extension code]
- phenylbutyrates [MeSH concept]
- phenylbutyrates [MeSH Descriptor]
Currated CISMeF NLP mapping
- 4-phenylbutyric acid, sodium salt [MeSH concept]
- Sodium phenylbutyrate (substance) [SNOMED CT concept]
False automatic mappings
- Product containing sodium phenylbutyrate (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 4-phenylbutyric acid, sodium salt [MeSH concept]
- Product containing sodium phenylbutyrate (medicinal product) [SNOMED CT concept]
- Sodium phenylbutyrate (substance) [SNOMED CT concept]
- sodium phenylbutyrate [ATC Code]
Validated automatic mappings to BTNT
- sodium phenylbutyrate [ATC Code]
chemical_or_drug_affects_gene_product
- Histone Deacetylase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Strand Break [NCIt concept]
- DNA Synthesis Inhibition [NCIt concept]
- Gene Regulation Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]
is_component_of_chemotherapy_regimen
- Azacitidine/Phenylbutyrate [NCIt concept]
- Dexamethasone/Phenylbutyrate/Sargramostim [NCIt concept]
- Fluorouracil/Phenylbutyrate [NCIt concept]
- Phenylbutyrate/Tretinoin [NCIt concept]

Keyword's position in hierarchy(ies) :

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