NCIt definition : A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Ivaltinosta
tinhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated
chromatin histones, followed by the induction of chromatin remodeling and an altered
pattern of gene expression. In particular, this agent enhances the histone acetylation
of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent
transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many
tumor types, deacetylates chromatin histone proteins.;
Semantic type(s)