" /> Ivaltinostat - CISMeF





Preferred Label : Ivaltinostat;

NCIt synonyms : (E)-N(1)-(3-(dimethylamino)propyl)-N(8)-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide; HDAC inhibitor CG200745;

NCIt definition : A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Ivaltinosta tinhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.;

UNII : 4I8MLM7L2H;

InChIKey : AUGCSOFQTDKPSO-RGVLZGJSSA-N;

CAS number : 936221-33-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 936221-33-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CG200745;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
12/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.