" /> Quisinostat - CISMeF





Preferred Label : Quisinostat;

NCIt synonyms : HDAC Inhibitor JNJ-26481585;

NCIt definition : An orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.;

UNII : 9BJ85K1J8S;

InChIKey : PAWIYAYFNXQGAP-UHFFFAOYSA-N;

CAS number : 875320-29-9;

Molecule name : JNJ-26481585; JNJ 26481585;

Chemical formula : C21H26N6O2;

Codes from synonyms : 425;

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07/05/2025


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