" /> Quisinostat - CISMeF





Preferred Label : Quisinostat;

NCIt synonyms : HDAC Inhibitor JNJ-26481585;

NCIt definition : An orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.;

UNII : 9BJ85K1J8S;

InChIKey : PAWIYAYFNXQGAP-UHFFFAOYSA-N;

CAS number : 875320-29-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 875320-29-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : JNJ-26481585;

Chemical formula : C21H26N6O2;

Codes from synonyms : 425;

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Keyword's position in hierarchy(ies) : arborescence

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09/05/2024


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