" /> Pracinostat - CISMeF





Preferred Label : Pracinostat;

NCIt synonyms : HDAC Inhibitor SB939; kaempferol 3-o-beta-d-(6-E-P-coumaroylglucoside); 2-propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1h-benzimidazol-5-yl)-N-hydroxy-, (2E)-;

NCIt related terms : SB939;

NCIt definition : An orally available, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. SB939 blocks the action of an enzyme called histone deacetylase (HDAC) and may stop tumor cells from dividing. It is a type of HDAC inhibitor.;

UNII : GPO2JN4UON;

InChIKey : JHDKZFFAIZKUCU-ZRDIBKRKSA-N;

CAS number : 929016-96-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 929016-96-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SB939;

Chemical formula : C20H30N4O2;

Codes from synonyms : CDR0000561416; 413;

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12/05/2024


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