Preferred Label : Anti-HER2/PBD-MA Antibody-drug Conjugate DHES0815A;
NCIt synonyms : Anti-HER2/PBD-MA ADC DHES0815A; Anti-HER2/PBD-Monoamide ADC DHES0815A; ADC DHES0815A;
NCIt related terms : DHES-0815A;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a monoclonal antibody targeting human
epidermal growth factor receptor 2 (ERBB2; EGFR2; HER2) linked to a DNA minor groove
crosslinking agent pyrrolo[2,1- c][1,4]benzodiazepine monoamide (PBD-MA), with potential
antineoplastic activity. Upon intravenous administration of ADC DHES0815A, the monoclonal
antibody moiety targets and binds to HER2 expressed on tumor cells. Following receptor
internalization and lysosome-mediated cleavage, the cytotoxic PBD-MA moiety is released.
In turn, the imine groups of the PBD-MA moiety bind to and crosslink specific sites
of DNA, resulting in DNA strand breaks, cell cycle arrest, and cell death in HER2
expressing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed by many
cancer cell types.;
UNII : 1E55T9OY5I;
Molecule name : DHES0815A;
NCI Metathesaurus CUI : CL562792;
Origin ID : C155940;
UMLS CUI : C4733671;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
