Preferred Label : Trastuzumab Botidotin;
NCIt synonyms : ADC A166; Anti-HER2 ADC A166; Anti-HER2 Antibody-drug Conjugate A166;
NCIt definition : An antibody-drug conjugate (ADC) composed of trastuzumab, a humanized monoclonal antibody
targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), conjugated,
via a cleavable linker, to the microtubule inhibitor and auristatin derivative duostatin-5
(Duo-5), with potential antineoplastic activity. Upon administration of trastuzumab
botidotin, the trastuzumab moiety targets and binds to HER2 on tumor cells. Upon antibody/antigen
binding and internalization, duo-5 binds to tubulin and inhibits its polymerization,
which results in cell cycle arrest and induces tumor cell apoptosis. HER2, a tyrosine
kinase receptor, is overexpressed by many cancer cell types.;
UNII : 6HUZ008AZX;
CAS number : 2699055-12-2;
Molecule name : A-166; A 166;
NCI Metathesaurus CUI : CL935677;
Origin ID : C156480;
UMLS CUI : C4744853;
Semantic type(s)
- concept_is_in_subset
- has_target
