NCIt definition : A cancer peptide vaccine comprised of four peptides derived from the tumor-associated
antigen (TAA) HER-2/neu (ErbB-2), with potential immunomodulating and antineoplastic
activities. Upon administration of the multi-epitope HER2 peptide vaccine TPIV100,
the four peptides may induce a cytotoxic T-lymphocyte (CTL)-mediated immune response
against tumor cells expressing the HER-2/neu antigen, which may result in the inhibition
of proliferation in Her-2/neu-expressing tumor cells. Her-2/neu, a member of the epidermal
growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various
tumor cell types. To enhance immunity, the peptides are admixed with the adjuvant
granulocyte macrophage-colony-stimulating factor (GM-CSF).;
Semantic type(s)