Preferred Label : Modified Vaccinia Ankara (Bavarian Nordic)-HER2 Vaccine;
NCIt synonyms : MVA-BN-HER2;
NCIt definition : A cancer vaccine consisting of a proprietary, recombinant modified vaccinia Ankara
(MVA) viral vector encoding an epitope of human epidermal growth factor receptor 2
(HER2) with potential antineoplastic activity. Upon administration, modified vaccinia
Ankara (Bavarian Nordic)-HER2 vaccine may stimulate the host immune system to mount
humoral and cytotoxic T lymphocyte responses against HER2-expressing tumor cells,
resulting in tumor cell lysis. HER2, also known as ErbB-2, is a tyrosine kinase growth
factor receptor and a member of the epidermal growth factor receptor family; it plays
a significant role in the pathogenesis of some breast cancers.;
NCI Metathesaurus CUI : CL376123;
Origin ID : C71758;
UMLS CUI : C2346919;
Semantic type(s)
- concept_is_in_subset
- has_target
