Preferred Label : Triciribine Phosphate;
NCIt synonyms : TCN; Tricycloside Phosphate; 1, 5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amine; Tricyclic Nucleoside 5'-Phosphate; 1,4,5,6, 8-pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl); 3-amino-1, 5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6, 8-pentaazaacenaphthylene
5'-(dihydrogen phosphate); 1,4, 5,6,8-pentaazaacenaphthylen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-
(9CI);
NCIt related terms : 3-Amino-1, 5-dihydro-5-methyl-1-.beta.-D-ribofuranosyl-1,4,5,6, 8-pentaazaacenaphthylene
5'-(dihydrogen phosphate); 1,4, 5,6,8-Pentaazaacenaphthylen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-
(9CI); Triciribine; 1, 5-Dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amine; 1,4,5,6, 8-Pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-;
NCIt definition : The phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine
with potential antineoplastic activity. Triciribine inhibits the phosphorylation,
activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition
of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific
protein kinases that phosphorylate and inactivate components of the apoptotic machinery,
including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9.;
UNII : 5L5GE3DV88;
InChIKey : URLYINUFLXOMHP-HTVVRFAVSA-N;
CAS number : 61966-08-3;
Chemical formula : C13H17N6O7P;
NSC code : 280594;
Codes from synonyms : NSC0280594; NSC0154020; 50714;
Origin ID : C1262;
UMLS CUI : C0077070;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
