Preferred Label : Akt Inhibitor LY2780301;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein
kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to
and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling
pathway, thereby leading to inhibition of cell proliferation and the induction of
apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently
associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to
tumor resistance to a variety of antineoplastic agents.;
Molecule name : LY2780301;
NCI Metathesaurus CUI : CL421578;
Origin ID : C95737;
UMLS CUI : C2987388;
Semantic type(s)
- concept_is_in_subset
- has_target
