p70S6K/Akt Inhibitor M-2698

Preferred Label : p70S6K/Akt Inhibitor M-2698;

NCIt synonyms : p70S6K/Akt Inhibitor MSC2363318A;

NCIt related terms : M-2698;

NCIt definition : An orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor M-2698 binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase.;

UNII : 0DXG50I4WD;

CAS number : 1379545-95-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1379545-95-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MSC2363318A;

NCI Metathesaurus CUI : CL454293;

Details

Origin ID

C112004;

UMLS CUI

C5667140;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase B [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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