Preferred Label : Rupitasertib;
NCIt synonyms : p70S6K/Akt Inhibitor MSC2363318A; p70S6K/Akt Inhibitor M-2698;
NCIt definition : An orally available inhibitor of the serine/threonine protein kinases ribosomal protein
S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity.
Upon administration, rupitasertib binds to and inhibits the activity of p70S6K and
Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits
tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K
signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K
pathway are frequently associated with tumorigenesis of many tumor types; targeting
multiple kinases in this pathway is more efficacious than targeting a single kinase.;
UNII : 0DXG50I4WD;
CAS number : 1379545-95-5;
Molecule name : M-2698; MSC-2363318A;
NCI Metathesaurus CUI : CL454293;
Origin ID : C112004;
UMLS CUI : C5667140;
Semantic type(s)
- concept_is_in_subset
- has_target
