Preferred Label : AKT 1/2 Inhibitor BAY1125976;
NCIt related terms : BAY-1125976;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein
kinase B) isoforms 1 and 2 (AKT1/2) with potential antineoplastic activity. AKT1/2
inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity
of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the
phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway.
This may lead to both the reduction of cell proliferation and the induction of cell
apoptosis in AKT-overexpressing tumor cells. The AKT signaling pathway is often deregulated
in cancer and is associated with tumor cell proliferation, survival and migration.;
UNII : ZL7A1UM87X;
CAS number : 1402608-02-9;
Molecule name : BAY1125976;
NCI Metathesaurus CUI : CL453983;
Origin ID : C111575;
UMLS CUI : C3827156;
Semantic type(s)
- concept_is_in_subset
- has_target
