" /> Pan-AKT Kinase Inhibitor GSK690693 - CISMeF





Preferred Label : Pan-AKT Kinase Inhibitor GSK690693;

NCIt synonyms : Pan-AKT Inhibitor GSK-690693;

NCIt related terms : GSK-690693;

NCIt definition : An aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport.;

UNII : GWH480321B;

CAS number : 937174-76-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 937174-76-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GSK690693;

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11/05/2024


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