Topical AKT Inhibitor SM-020

Preferred Label : Topical AKT Inhibitor SM-020;

NCIt synonyms : SM-020 Topical Gel;

NCIt definition : A topical gel formulation of an inhibitor of the serine/threonine protein kinase AKT (protein kinase B), with potential antineoplastic activity. Upon application, the topical AKT inhibitor SM-020 binds to and inhibits the activity of AKT, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is associated with tumor cell proliferation, survival and migration.;

Molecule name : SM-020; SM 020;

NCI Metathesaurus CUI : CL1921695;

Details

Origin ID

C202903;

UMLS CUI

C5907980;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase B [NCIt concept]

Keyword's position in hierarchy(ies) :

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