Preferred Label : Topical AKT Inhibitor SM-020;
NCIt synonyms : SM-020 Topical Gel;
NCIt definition : A topical gel formulation of an inhibitor of the serine/threonine protein kinase AKT
(protein kinase B), with potential antineoplastic activity. Upon application, the
topical AKT inhibitor SM-020 binds to and inhibits the activity of AKT, which may
result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction
in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling
pathway is associated with tumor cell proliferation, survival and migration.;
Molecule name : SM-020; SM 020;
Origin ID : C202903;
concept_is_in_subset
- has_target
