Preferred Label : Serine/Threonine Kinase Inhibitor XL418;
NCIt synonyms : Serine Threonine Kinase Inhibitor XL418;
NCIt related terms : XL-418;
NCIt definition : A selective, orally active small molecule, targeting protein kinase B (PKB or AKT)
and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity.
XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3
kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition
of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result
in the inhibition of translation within tumor cells.;
UNII : OLJ18SRI8A;
CAS number : 871343-09-8;
Molecule name : XL418;
NCI Metathesaurus CUI : CL374493;
Origin ID : C68963;
UMLS CUI : C2348194;
Semantic type(s)
- concept_is_in_subset
- has_target
