Serine/Threonine Kinase Inhibitor XL418

Preferred Label : Serine/Threonine Kinase Inhibitor XL418;

NCIt synonyms : Serine Threonine Kinase Inhibitor XL418;

NCIt related terms : XL-418;

NCIt definition : A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.;

UNII : OLJ18SRI8A;

CAS number : 871343-09-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 871343-09-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : XL418;

NCI Metathesaurus CUI : CL374493;

Details

Origin ID

C68963;

UMLS CUI

C2348194;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase B [NCIt concept]

Keyword's position in hierarchy(ies) :

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