Preferred Label : Pan-AKT Inhibitor LY2503029;
NCIt synonyms : AKT Inhibitor LY2503029;
NCIt definition : An orally bioavailable pan-inhibitor of the serine/threonine protein kinase AKT (protein
kinase B; v-akt murine thymoma viral oncogene homolog 1), with potential antineoplastic
activity. Upon oral administration, pan-AKT inhibitor LY2503029 targets, binds to
and inhibits the activity of the AKT isoforms 1, 2 and 3, which may result in the
inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. This
may inhibit proliferation and induce apoptosis of tumor cells in which AKT is overexpressed.
Activation of the PI3K/AKT signaling pathway is frequently associated with tumorigenesis
and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety
of antineoplastic agents.;
Molecule name : LY-2503029; LY 2503029;
NCI Metathesaurus CUI : CL1792208;
Origin ID : C187285;
UMLS CUI : C5706389;
Semantic type(s)
- concept_is_in_subset
- has_target
