NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein
kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits
the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition
of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of
tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated
with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance
to a variety of antineoplastic agents.;
UNII : 524Y3IB4HQ;
InChIKey : GRZXWCHAXNAUHY-NSISKUIASA-N;
CAS number : 1001264-89-6;
Molecule name : GDC-0068; RG-7440; RG 7440; GDC 0068;