" /> Ipatasertib - CISMeF





Preferred Label : Ipatasertib;

NCIt synonyms : (2S)-2-(4-chlorophenyl)-1-(4-((5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl(-3-((propan-2-yl)amino)propan-1-one;

NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.;

UNII : 524Y3IB4HQ;

InChIKey : GRZXWCHAXNAUHY-NSISKUIASA-N;

CAS number : 1001264-89-6;

Molecule name : GDC-0068; RG-7440; RG 7440; GDC 0068;

Codes from synonyms : 278;

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Keyword's position in hierarchy(ies) : arborescence

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28/05/2025


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