Preferred Label : Olverembatinib;
NCIt synonyms : Multi-kinase Inhibitor HQP1351; BCR-ABL/KIT/AKT/ERK Inhibitor HQP1351;
NCIt definition : An orally bioavailable inhibitor of a variety of kinases, including the Bcr-Abl tyrosine
kinase, the mast/stem cell growth factor receptor Kit (c-Kit), the serine/threonine
protein kinase Akt (protein kinase B), and the extracellular signal-regulated kinase
(ERK) with antineoplastic activity. Upon administration,olverembatinib targets, binds
to and inhibits the kinase activities of Bcr-Abl, AKT, c-Kit and ERK. This inhibits
their mediated signaling pathways and inhibits proliferation of tumor cells in which
these kinases are overexpressed and/or mutated. Bcr-Abl, c-Kit, AKT and ERK play key
roles in the proliferation, differentiation and survival of tumor cells.;
UNII : KV1M7Q3CBP;
InChIKey : TZKBVRDEOITLRB-UHFFFAOYSA-N;
CAS number : 1257628-77-5;
Molecule name : HQP-1351; HQP 1351; GZD-824;
Codes from synonyms : 120610;
Origin ID : C165549;
UMLS CUI : C5432353;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
