Bryostatin 1 - CISMeF

Preferred Label : Bryostatin 1;

NCIt synonyms : Bryostatin-1;

NCIt related terms : Bryostatin I; B705008K112;

NCIt definition : A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer and certain brain conditions such as Alzheimer disease and stroke. It binds to an enzyme involved in cell growth and it may help anticancer drugs work better. Bryostatin 1 comes from a marine organism. It is a type of protein kinase C modulator.;

UNII : 37O2X55Y9E;

InChIKey : MJQUEDHRCUIRLF-TVIXENOKSA-N;

CAS number : 83314-01-6;

Molecule name : B705008K112;

Chemical formula : C47H68O17;

NSC code : 339555;

Codes from synonyms : 01979; NSC0339555; CDR0000045630;

Details

Origin ID

C1026;

UMLS CUI

C0054173;

Currated CISMeF NLP mapping
- bryostatin 1 [MeSH concept]
- bryostatin 1 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- bryostatin 1 [MeSH concept]
- bryostatin 1 [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Protein Kinase C [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase C [NCIt concept]
is_component_of_chemotherapy_regimen
- Bryostatin 1/Cisplatin [NCIt concept]
- Bryostatin 1/Cladribine [NCIt concept]
- Bryostatin 1/Cytarabine [NCIt concept]
- Bryostatin 1/Fludarabine [NCIt concept]
- Bryostatin 1/Gemcitabine [NCIt concept]
- Bryostatin 1/Interleukin-2 [NCIt concept]
- Bryostatin 1/Interleukin-2/Ionomycin [NCIt concept]
- Bryostatin 1/Paclitaxel [NCIt concept]
- Bryostatin 1/Sargramostim [NCIt concept]
- Bryostatin 1/Tretinoin [NCIt concept]
- Bryostatin 1/Vincristine [NCIt concept]

Keyword's position in hierarchy(ies) :

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