Preferred Label : Enzastaurin Hydrochloride;
NCIt synonyms : 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Dihydrochloride; Enzastaurin Monohydrochloride; 1H-Pyrrole-2,5-dione, 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(2-pyridinylmethyl)-4-piperidinyl)-1H-indol-3-yl)-,
Monohydrochloride;
NCIt related terms : LY317615;
NCIt definition : The hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide
with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin
selectively inhibits protein kinase C beta, an enzyme involved in the induction of
vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent
may decrease tumor blood supply and so tumor burden.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain types of cancer,
including non-Hodgkin lymphoma, breast, colon, lung, ovarian, and prostate. Enzastaurin
hydrochloride blocks certain cell signaling pathways, and may prevent the growth of
new blood vessels that tumors need to grow. It is a type of serine threonine kinase
inhibitor and a type of antiangiogenesis agent.;
UNII : KX7K68Z2UH;
InChIKey : UUADYKVKJIMIPA-UHFFFAOYSA-N;
CAS number : 359017-79-1;
Molecule name : LY317615;
Chemical formula : C32H29N5O2.HCl;
Codes from synonyms : CDR0000285925; CDR0000513020; 50606;
Origin ID : C26658;
UMLS CUI : C1765315;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
