Gold Sodium Thiomalate

Preferred Label : Gold Sodium Thiomalate;

NCIt synonyms : Aurothiomalate Disodium;

NCIt definition : The sodium salt of gold thiomalic acid, an organogold compound with antirheumatic and potential antineoplastic activities. Gold sodium thiomalate (GST) appears to inhibit the activity of atypical protein kinase C iota (PKCiota) by forming a cysteinyl-aurothiomalate adduct with the cysteine residue Cys-69 within the PB1 binding domain of PKCiota. This prevents the binding of Par6 (Partitioning defective protein 6) to PKCiota, thereby inhibiting PKCiota-mediated oncogenic signaling, which may result in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. Atypical PKCiota, a serine/threonine kinase overexpressed in numerous cancer cell types, plays an important role in cancer proliferation, invasion, and survival; Par6 is a scaffold protein that facilitates atypical PKC-mediated phosphorylation of cytoplasmic proteins involved in epithelial and neuronal cell polarization.;

UNII : E4768ZY6GM;

CAS number : 12244-57-4;

Drug name : Aurolate; Myochrysine;

ChEBI ID : CHEBI:5516;

Details

Origin ID

C74037;

UMLS CUI

C0018034;

See also inter- (CISMeF)
- Product containing sodium aurothiomalate (medicinal product) [SNOMED CT concept]
- Sodium aurothiomalate [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sodium aurothiomalate (medicinal product) [SNOMED CT concept]
- Sodium aurothiomalate [ICD-11 Extension code]
- Sodium aurothiomalate (substance) [SNOMED CT concept]
- gold sodium thiomalate [MeSH concept]
- gold sodium thiomalate [MeSH Descriptor]
- gold sodium thiomalate [SNOMED Notion]
- sodium aurothiomalate [ATC Code]
- sodium aurothiomalate [Substance BNPC]
Validated automatic mappings to BTNT
- sodium aurothiomalate [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase C Iota Type [NCIt concept]

Keyword's position in hierarchy(ies) :

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