Alpha-Actinin-4

Preferred Label : Alpha-Actinin-4;

NCIt synonyms : Non-Muscle Alpha-Actinin 4; Actinin Alpha4 Isoform; ACTN4;

NCIt definition : Alpha-actinin-4 (911 aa, 105 kDa) is encoded by the human ACTN4 gene. This protein plays a role in actin crosslinking.;

NCIt note : Alpha-actinin-4 may also act as a transcriptional coactivator for certain nuclear receptors. (UniProt);

Details

Origin ID

C126634;

UMLS CUI

C1308458;

Automatic exact mappings (from CISMeF team)
- Actinin, alpha-4 [OMIM gene]
- actinin alpha 4 [ORDO Gene]
OMIM relation
- Actinin, alpha-4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ACTN4 protein, human [MeSH Supplementary Concept]
- ACTN4 protein, human [MeSH concept]
gene_encodes_gene_product
- ACTN4 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cell Junction [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
- Calcium Binding Protein [NCIt concept]
- Scaffolding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EF-Hand Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Intracellular Transport [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients