Selenoprotein N

Preferred Label : Selenoprotein N;

NCIt synonyms : SEPN1; SELENON; SelN;

NCIt definition : Selenoprotein N (590 aa, 66 kDa) is encoded by the human SELENON gene. This protein plays a role in regulating organismal and cellular responses to oxidative stress and the modulation of ryanodine receptor (RyR) activity.;

NCIt note : In the UniProt canonical isoform of selenoprotein N (isoform 1), the UGA codons present in position 127 and 462 are either a selenocysteine or a real stop codon. While in isoform 2, the UGA codon present in position 428 is either a selenocysteine or a real stop codon.;

Details

Origin ID

C205073;

OMIM relation
- Selenoprotein n [OMIM gene]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SELENON Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EF-Hand Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Calcium Homeostasis [NCIt concept]
- Myogenesis [NCIt concept]
- Positive Regulation of Oxidative Stress Process [NCIt concept]

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