Stromal Interaction Molecule 1

Preferred Label : Stromal Interaction Molecule 1;

NCIt synonyms : STIM1; Stromal Interaction Molecule-1;

NCIt definition : Stromal interaction molecule 1 (685 aa, 77 kDa) is encoded by the human STIM1 gene. This protein is involved in the modulation of calcium transport by stimulating calcium channel formation.;

NCIt note : Stromal interaction molecule 1 forms homooligomers and heterooligomers with stromal interaction molecule 2. (UniProt);

Détails

Origin ID

C21219;

UMLS CUI

C1430594;

OMIM relation
- Stromal interaction molecule 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- STIM1 protein, human [MeSH concept]
- STIM1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- STIM1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EF-Hand Domain [NCIt concept]
- SAM Domain [NCIt concept]
- Signal Peptide [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_malfunction_associated_with_disease
- Rhabdoid Tumor [NCIt concept]
- Rhabdomyosarcoma [NCIt concept]
gene_product_plays_role_in_biological_process
- B Cell Proliferation [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Ion Transport Process [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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