SAM Domain - CISMeF

Preferred Label : SAM Domain;

NCIt synonyms : Sterile Alpha Domain; SAM Motif; Sterile Alpha Motif;

NCIt definition : The approximately 70 amino acid SAM (Sterile Alpha Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating protein-protein interaction via the formation of homo and hetero-typic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003);

Details

Origin ID

C13960;

UMLS CUI

C1519124;

Automatic exact mappings (from CISMeF team)
- Sterile Alpha Motif [MeSH Descriptor]
- Sterile Alpha Motif [MeSH concept]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- Sterile Alpha Motif [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- Connector Enhancer of Kinase Suppressor of Ras 1 [NCIt concept]
- Liprin-Beta-1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 2 [NCIt concept]
- Poly [ADP-Ribose] Polymerase Tankyrase-1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase Tankyrase-2 [NCIt concept]
- Protein Bicaudal C Homolog 1 [NCIt concept]
- SAM Domain and HD Domain-Containing Protein 1 [NCIt concept]
- SH3 and Multiple Ankyrin Repeat Domains Protein 2 [NCIt concept]
- Sterile Alpha Motif Domain-Containing Protein 9 [NCIt concept]
- Sterile Alpha Motif Domain-Containing Protein 9-Like [NCIt concept]
- Sterile Alpha and TIR Motif-Containing Protein 1 [NCIt concept]
- Stromal Interaction Molecule 1 [NCIt concept]
- Usher Syndrome Type-1G Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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