Poly [ADP-Ribose] Polymerase Tankyrase-2

Preferred Label : Poly [ADP-Ribose] Polymerase Tankyrase-2;

NCIt synonyms : Tankyrase-Related Protein; ARTD6; Tankyrase-Like Protein; Protein Poly-ADP-Ribosyltransferase Tankyrase-2; Tankyrase 2; TNKS-2; TANK2; ADP-Ribosyltransferase Diphtheria Toxin-Like 6; Tankyrase II; TNKS2; EC 2.4.2.30; Tankyrase-2; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2; Poly [ADP-Ribose] Polymerase 5B;

NCIt definition : Poly [ADP-ribose] polymerase tankyrase-2 (1166 aa, 127 kDa) is encoded by the human TNKS2 gene. This protein is involved in poly-ADP-ribosylation of protein substrates and regulates telomere maintenance and protein ubiquitination and degradation.;

Details

Origin ID

C187076;

UMLS CUI

C1448153;

OMIM relation
- Tankyrase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TNKS2 protein, human [MeSH Supplementary Concept]
- TNKS2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Glycosyltransferase Gene [NCIt concept]
- TNKS2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ankyrin Repeat [NCIt concept]
- SAM Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Telomerase Regulation Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Glycosylation [NCIt concept]
- Poly-ADP-Ribosylation [NCIt concept]
- Telomere Maintenance [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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