Ankyrin Repeat

Preferred Label : Ankyrin Repeat;

NCIt synonyms : Ankyrin Repeat Domain; ANK Repeat; ANK Domain;

NCIt definition : Ankyrin Repeats are tandem modules of about 33 amino acids. The conserved domain structure has been described as side-by-side anti-parallel alpha helices connected by intervening beta hairpin motifs or as beta, alpha, alpha, beta secondary structures or as an L-shaped beta-hairpin and two alpha-helices. The repeats associate to form a higher order structure. Despite sequence variation, the domain core maintains a stable surface of contact residues to mediate protein-protein interactions. Target protein binding involves contacts by the beta hairpin tips and the helical bundle surface facing the Ankyrin groove. ANK repeats have been identified in over 1700 functionally diverse proteins, primarily from eukaryotes; no common theme among the protein targets has been identified. The Ankyrin cytoskeletal protein is composed almost entirely of these repeats.;

Details

Origin ID

C14100;

UMLS CUI

C0162527;

Automatic exact mappings (from CISMeF team)
- ANK repeat domains [MeSH concept]
Currated CISMeF NLP mapping
- ankyrin repeat [MeSH Descriptor]
- ankyrin repeat [MeSH concept]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- ankyrin repeat [MeSH concept]
- ankyrin repeat [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- 2-5A-Dependent Ribonuclease [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 10 [NCIt concept]
- 85 kDa Calcium-Independent Phospholipase A2 [NCIt concept]
- ARF GTPase-Activating Protein GIT1 [NCIt concept]
- ARF GTPase-Activating Protein GIT2 [NCIt concept]
- Acyl-CoA-Binding Domain-Containing Protein 6 [NCIt concept]
- Ankyrin Repeat Domain-Containing Protein 11 [NCIt concept]
- Ankyrin Repeat Domain-Containing Protein 24 [NCIt concept]
- Ankyrin Repeat Domain-Containing Protein 26 [NCIt concept]
- Ankyrin Repeat Domain-Containing Protein 30A [NCIt concept]
- Ankyrin Repeat and BTB/POZ Domain-Containing Protein 2 [NCIt concept]
- Ankyrin Repeat and SOCS Box Protein 2 [NCIt concept]
- Ankyrin-2 [NCIt concept]
- Apoptosis-Stimulating of p53 Protein 1 [NCIt concept]
- Apoptosis-Stimulating of p53 Protein 2 [NCIt concept]
- Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain-Containing 1 [NCIt concept]
- BCL-6 Corepressor [NCIt concept]
- BCL-6 Corepressor-Like Protein 1 [NCIt concept]
- BRCA1-Associated RING Domain Protein 1 [NCIt concept]
- Calmodulin-Binding Transcription Activator 1 [NCIt concept]
- Cyclin-Dependent Kinase 4 Inhibitor C [NCIt concept]
- Cyclin-Dependent Kinase 4 Inhibitor D [NCIt concept]
- DNA-Binding Protein RFXANK [NCIt concept]
- Death-Associated Protein Kinase 1 [NCIt concept]
- Diacylglycerol Kinase Zeta [NCIt concept]
- E3 Ubiquitin-Protein Ligase HACE1 [NCIt concept]
- Espin [NCIt concept]
- Glutaminase Liver Isoform, Mitochondrial [NCIt concept]
- I Kappa B [NCIt concept]
- Integrin-Linked Protein Kinase [NCIt concept]
- Krev Interaction Trapped Protein 1 [NCIt concept]
- Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- NF-Kappa-B Inhibitor Delta [NCIt concept]
- NF-Kappa-B Inhibitor Epsilon [NCIt concept]
- NF-Kappa-B Inhibitor Zeta [NCIt concept]
- Neurogenic Locus Notch Homolog Protein 1 [NCIt concept]
- Neurogenic Locus Notch Homolog Protein 2 [NCIt concept]
- Neurogenic Locus Notch Homolog Protein 3 [NCIt concept]
- Neurogenic Locus Notch Homolog Protein 4 [NCIt concept]
- Notch-Regulated Ankyrin Repeat-Containing Protein [NCIt concept]
- Nuclear Factor NF-kappa-B p100 Subunit [NCIt concept]
- Nuclear Factor NF-kappa-B p105 Subunit [NCIt concept]
- Poly [ADP-Ribose] Polymerase Tankyrase-1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase Tankyrase-2 [NCIt concept]
- Protein Fem-1 Homolog C [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 4 [NCIt concept]
- RelA-Associated Inhibitor [NCIt concept]
- SH3 and Multiple Ankyrin Repeat Domains Protein 3 [NCIt concept]
- Short Transient Receptor Potential Channel 4 [NCIt concept]
- Synphilin-1 [NCIt concept]
- TPR and Ankyrin Repeat-Containing Protein 1 [NCIt concept]
- Tonsoku-Like Protein [NCIt concept]
- Transient Receptor Potential Cation Channel Subfamily A Member 1 [NCIt concept]
- Transient Receptor Potential Cation Channel Subfamily V Member 4 [NCIt concept]
- Transient Receptor Potential Cation Channel Subfamily V Member 6 [NCIt concept]
- Usher Syndrome Type-1G Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients