E3 Ubiquitin-Protein Ligase HACE1

Preferred Label : E3 Ubiquitin-Protein Ligase HACE1;

NCIt synonyms : EC 6.3.2.-, Formerly; HECT Domain and Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1; HECT Domain- and Ankyrin Repeat-Containing E3 Ubiquitin Protein Ligase 1; EC 2.3.2.26;

NCIt definition : E3 ubiquitin-protein ligase HACE1 (909 aa, 102 kDa) is encoded by the human HACE1 gene. This protein is involved in the regulation of both the ubiquitination and subsequent degradation of small GTPases, which modulates Golgi membrane dynamics.;

Details

Origin ID

C119639;

UMLS CUI

C1566616;

Automatic exact mappings (from CISMeF team)
- HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [ORDO Gene]
- Hect domain- and ankyrin repeat-containing e3 ubiquitin protein ligase 1 [OMIM gene]
OMIM relation
- Hect domain- and ankyrin repeat-containing e3 ubiquitin protein ligase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HACE1 protein, human [MeSH Supplementary Concept]
- HACE1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HACE1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Golgi Apparatus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ankyrin Repeat [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Membrane Fusion Activity [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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