" /> Nuclear Factor NF-kappa-B p100 Subunit - CISMeF





Preferred Label : Nuclear Factor NF-kappa-B p100 Subunit;

NCIt synonyms : NF-Kappa B p49-p100 Protein; DNA-Binding Factor KBF2; Nuclear Factor Kappa B Subunit 2; Lyt10; H2TF1; NF-kappaB(p50); NFKB2 Protein; Transcription Factor NFKB2; Lymphocyte Translocation Chromosome 10 Protein; Nuclear Factor of Kappa Light Chain Gene Enhancer in B-Cells 2; NF-Kappa B p49/p100; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 2; Nuclear Factor Kappa-B Subunit 2; NFKB2; NF-kappa-B2; LYT10 Protein; Oncogene Lyt-10; NFKB p49/p100 Subunit; NF-kB Subunit 2;

NCIt definition : Nuclear factor NF-kappa-B p100 subunit (900 aa, 97 kDa) is encoded by the human NFKB2 gene. This protein plays a role in both transcriptional regulation and signal transduction.;

NCIt note : 100Kd and 49Kd products by alternate splicing; Nuclear factor NF-kappa-B p100 subunit is proteolytically processed to form nuclear factor NF-kappa-B p52 subunit.; NFKB2 belongs to the Rel/Dorsal family, contains seven ANK repeats, and binds to REL (p65) proteins to form NFKB, which is trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (from SWISS-PROT Q00653, OMIM 164012, and NCI);

NCI Metathesaurus CUI : CL1770516;

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15/05/2024


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