Preferred Label : NF-kB;
NCIt synonyms : Nuclear Transcription Factor NF-kB; NFKB; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells; Nuclear Factor Kappa-B; Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells; NF-Kappa B; Nuclear Factor Kappa B; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells; Nuclear Factor NF-Kappa-B; NF-KappaB; NF-Kappa-B;
NCIt definition : NF-kB is a heterodimer complex of two DNA-binding subunits from two families of ubiquitous,
inducible, nuclear transcription activators involved in cytokine-induced activation
of gene expression. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kB
complex. NF-kB is inhibited by IkB proteins (NFKBIA or NFKBIB), which inactivate NF-kB
by trapping it in the cytoplasm. Phosphorylation of IkB by kinases (IKBKA or IKBKB)
marks them for ubiquitination, allowing NF-kB translocation to the nucleus and DNA
binding at kappa-B transcription enhancer motifs. In B-lymphocytes, NF-kB binds to
the immunoglobulin kappa light chain enhancer and in T-lymphocytes it binds to enhancers
in virally infected cells, including HIV. (from OMIM 164011, 164012, 164910, 164014,
604758, and NCI);
Origin ID : C17380;
UMLS CUI : C0079904;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_product_has_biochemical_function
- gene_product_plays_role_in_biological_process
- has_gene_product_element
