Nuclear Factor NF-kappa-B p105 Subunit

Preferred Label : Nuclear Factor NF-kappa-B p105 Subunit;

NCIt synonyms : DNA-Binding Factor KBF1; EBP-1; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 1;

NCIt definition : Nuclear factor NF-kappa-B p105 subunit (968 aa, 105 kDa) is encoded by the human NFKB1 gene. This protein is involved in the mediation of signal transduction, the regulation of apoptosis and the modulation of transcription.;

NCIt note : Nuclear factor NF-kappa-B p105 subunit is cleaved by the 26S proteasome to release nuclear factor NF-kappa-B p50 subunit.;

Details

Origin ID

C94300;

UMLS CUI

C2986465;

OMIM relation
- Nuclear factor kappa-b, subunit 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- NFKB1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ankyrin Repeat [NCIt concept]
- Death Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Atypical NF-kappaB Signaling Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Cancer Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
gene_product_is_physical_part_of
- NF-kB [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- DNA Binding [NCIt concept]
- Immune Response Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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