Nuclear Factor NF-kappa-B p50 Subunit

Preferred Label : Nuclear Factor NF-kappa-B p50 Subunit;

NCIt synonyms : NF-kB Subunit 1 p50; NF-kappaB(p50); NFKB p50 Subunit; NF-Kappa B p50; Nuclear Factor Kappa-B Subunit 1 p50;

NCIt definition : Nuclear factor NF-kappa-B p50 subunit (433 aa, 48 kDa) is encoded by the human NFKB1 gene. This protein is involved in both transcriptional regulation and signal transduction.;

NCIt note : Nuclear factor NF-kappa-B p105 subunit is cleaved by the 26S proteasome to release nuclear factor NF-kappa-B p50 subunit.;

NCI Metathesaurus CUI : CL514234;

Details

Origin ID

C131127;

UMLS CUI

C1452413;

Automatic exact mappings (from CISMeF team)
- nf-kappa b p50 subunit [MeSH Descriptor]
OMIM relation
- Nuclear factor kappa-b, subunit 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NFKB1 protein, human [MeSH Supplementary Concept]
- NFKB1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- NFKB1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_physical_part_of
- NF-kB [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- DNA Binding [NCIt concept]
- Immune Response Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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