" /> 26S Proteasome Non-ATPase Regulatory Subunit 10 - CISMeF





Preferred Label : 26S Proteasome Non-ATPase Regulatory Subunit 10;

NCIt synonyms : PSMD10; Gankyrin; Hepatocellular Carcinoma-Associated Protein p28-II; 26S Proteasome Regulatory Subunit p28; p28(GANK); Ankyrin Repeat Protein; Proteasome 26S Subunit, Non-ATPase, 10; Proteasome-26S Subunit Non-ATPase-10; Proteasome 26S Subunit Non-ATPase 10;

NCIt definition : 26S proteasome non-ATPase regulatory subunit 10 (226 aa, 24 kDa) is encoded by the human PSMD10 gene. This protein is involved in both the assembly of the 26S proteasome, ubiquitin-dependent protein degradation and signaling pathway regulation.;

NCIt note : The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This protein is a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink);

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16/05/2024


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