Polyubiquitination

Preferred Label : Polyubiquitination;

NCIt definition : The type of ubiquitin modification determines the functional consequences for the modified protein. Polyubiquitination, which involves chains of usually four or more ubiquitins, typically seen on cytoplasmic proteins, serve as an efficient signal for recognition by the proteasome and subsequent protein degradation. (From PMID and NCI);

Details

Origin ID

C21587;

UMLS CUI

C1514216;

Automatic exact mappings (from CISMeF team)
- Ubiquitin C [OMIM gene]
- obsolete polyubiquitin [GO term]
- polyubiquitin [MeSH concept]
- polyubiquitin [MeSH Descriptor]
- protein polyubiquitination [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_involves_gene_product
- 26S Proteasome Non-ATPase Regulatory Subunit 10 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 2 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 3 [NCIt concept]
- DNA Damage-Binding Protein 2 [NCIt concept]
- Denticleless Protein Homolog [NCIt concept]
- E3 Ubiquitin Ligase TRAF3IP2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Arkadia [NCIt concept]
- E3 Ubiquitin-Protein Ligase BRE1A [NCIt concept]
- E3 Ubiquitin-Protein Ligase Parkin [NCIt concept]
- E3 Ubiquitin-Protein Ligase Pellino Homolog 3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF31 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- RanBP-Type and C3HC4-Type Zinc Finger-Containing Protein 1 [NCIt concept]
- Sharpin [NCIt concept]
- Short Transient Receptor Potential Channel 4-Associated Protein [NCIt concept]
- Speckle-Type POZ Protein [NCIt concept]
- Ubiquitin Conjugation Factor E4 B [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 N [NCIt concept]
biological_process_is_part_of_process
- Post-Translational Regulation [NCIt concept]
- Protein Degradation Process [NCIt concept]
process_involves_gene
- DDB2 Gene [NCIt concept]
- DDB2 wt Allele [NCIt concept]
- DTL Gene [NCIt concept]
- DTL wt Allele [NCIt concept]
- PELI3 Gene [NCIt concept]
- PELI3 wt Allele [NCIt concept]
- PRKN Gene [NCIt concept]
- PRKN wt Allele [NCIt concept]
- PSMD10 Gene [NCIt concept]
- PSMD10 wt Allele [NCIt concept]
- PSMD2 Gene [NCIt concept]
- PSMD2 wt Allele [NCIt concept]
- PSMD3 Gene [NCIt concept]
- PSMD3 wt Allele [NCIt concept]
- RBCK1 Gene [NCIt concept]
- RBCK1 wt Allele [NCIt concept]
- RNF111 Gene [NCIt concept]
- RNF111 wt Allele [NCIt concept]
- RNF20 Gene [NCIt concept]
- RNF20 wt Allele [NCIt concept]
- RNF31 Gene [NCIt concept]
- RNF31 wt Allele [NCIt concept]
- RNF5 Gene [NCIt concept]
- RNF5 wt Allele [NCIt concept]
- SHARPIN Gene [NCIt concept]
- SHARPIN wt Allele [NCIt concept]
- SMURF2 Gene [NCIt concept]
- SMURF2 wt Allele [NCIt concept]
- SPOP Gene [NCIt concept]
- SPOP wt Allele [NCIt concept]
- TRAF3IP2 Gene [NCIt concept]
- TRAF3IP2 wt Allele [NCIt concept]
- UBE2N Gene [NCIt concept]
- UBE2N wt Allele [NCIt concept]
- UBE4B Gene [NCIt concept]
- UBE4B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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