E3 Ubiquitin-Protein Ligase SMURF2

Preferred Label : E3 Ubiquitin-Protein Ligase SMURF2;

NCIt synonyms : SMAD Specific E3 Ubiquitin Protein Ligase 2; SMAD Ubiquitination Regulatory Factor 2; HECT-Type E3 Ubiquitin Transferase SMURF2; E3 Ubiquitin Ligase SMURF2; EC 2.3.2.26; SMURF2; SMAD-Specific E3 Ubiquitin-Protein Ligase 2; hSMURF2;

NCIt definition : E3 ubiquitin-protein ligase SMURF2 (748 aa, 86 kDa) is encoded by the human SMURF2 gene. This protein is involved in the modulation of SMAD/TGF-beta receptor complex degradation.;

Details

Origin ID

C185004;

UMLS CUI

C0962942;

Automatic exact mappings (from CISMeF team)
- SMAD specific E3 ubiquitin protein ligase 2 [HGNC gene]
- Smad-specific e3 ubiquitin protein ligase 2 [OMIM gene]
OMIM relation
- Smad-specific e3 ubiquitin protein ligase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SMURF2 protein, human [MeSH Supplementary Concept]
- SMURF2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- SMURF2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- BMP Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Polyubiquitination [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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