E3 Ubiquitin-Protein Ligase Parkin

Preferred Label : E3 Ubiquitin-Protein Ligase Parkin;

NCIt synonyms : EC 2.3.2.31; Parkinson Juvenile Disease Protein 2; Parkin; Parkinson Disease Protein 2; EC 6.3.2.-, Formerly; Parkin RBR E3 Ubiquitin-Protein Ligase; Parkinson Protein 2 E3 Ubiquitin Protein Ligase; PRKN;

NCIt definition : E3 ubiquitin-protein ligase parkin (465 aa, 52 kDa) is encoded by the human PRKN gene. This protein may play a role in the ubiquitination of proteins targeted for proteasomal degradation.;

NCIt note : E3 ubiquitin-protein ligase parkin is an atypical E3 ligase in the RBR (RING-betweenRING-RING) family. RBR E3 ligases are characterized by two RING fingers separated by a cysteine-rich RING region. (InterPro);

Details

Origin ID

C90313;

UMLS CUI

C1311470;

OMIM relation
- Parkin rbr e3 ubiquitin protein ligase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PARK 2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PRKN Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Parkinson's Disease Pathway KEGG [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_malfunction_associated_with_disease
- Parkinson Disease [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Polyubiquitination [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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