Ubiquitin-Conjugating Enzyme E2 N

Preferred Label : Ubiquitin-Conjugating Enzyme E2 N;

NCIt synonyms : UbcH13; Bendless-Like Ubiquitin-Conjugating Enzyme; Ubc13; Ubiquitin Carrier Protein N; EC 6.3.2.19, Formerly; Epididymis Secretory Protein Li 71; Bendless-Like Ubiquitin Conjugating Enzyme; EC 2.3.2.23; UBE2N; Ubiquitin-Protein Ligase N; E2 Ubiquitin-Conjugating Enzyme N;

NCIt definition : Ubiquitin-conjugating enzyme E2 N (152 aa, 17 kDa) is encoded by the human UBE2N gene. This protein plays a role in the polyubiquitination of protein substrates, which may regulate transcription.;

NCIt note : Ubiquitin-conjugating enzyme E2 N is active when in a heterodimeric complex with either ubiquitin-conjugating enzyme E2 variant 1 or ubiquitin-conjugating enzyme E2 variant 2. The activity of these heterodimeric enzymes does not lead to proteasomal degradation of their substrates. (UniProt);

Details

Origin ID

C119648;

UMLS CUI

C1174531;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-conjugating enzyme e2 n [OMIM gene]
OMIM relation
- Ubiquitin-conjugating enzyme e2 n [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- UBE2N protein, human [MeSH Supplementary Concept]
- UBE2N protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- UBE2N Gene [NCIt concept]
- Ubiquitin-Conjugating Enzyme Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- IL1-Mediated Signaling Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Polyubiquitination [NCIt concept]
- Signal Transduction Induction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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