" /> Ubiquitin Conjugation Factor E4 B - CISMeF





Preferred Label : Ubiquitin Conjugation Factor E4 B;

NCIt synonyms : Ubiquitin Fusion Degradation Protein 2; Homozygously Deleted In Neuroblastoma 1; EC 2.3.2.27; RING-Type E3 Ubiquitin Transferase E4 B;

NCIt definition : Ubiquitin conjugation factor E4 B (1302 aa, 146 kDa) is encoded by the human UBE4B gene. This protein plays a role in the mediation of polyubiquitination.;

NCIt note : Ubiquitin conjugation factor E4 B interacts with E3 ubiquitin-protein ligase Mdm2 to ubiquitinylate cellular tumor antigen p53. This targets cellular tumor antigen p53 to the proteasome for degradation. (Nature Medicine. 2011; DOI: 10.1038/nm.2283.);

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31/07/2025


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