Ubiquitin Conjugation Factor E4 B

Preferred Label : Ubiquitin Conjugation Factor E4 B;

NCIt synonyms : Ubiquitin Fusion Degradation Protein 2; Homozygously Deleted In Neuroblastoma 1; EC 2.3.2.27; RING-Type E3 Ubiquitin Transferase E4 B;

NCIt definition : Ubiquitin conjugation factor E4 B (1302 aa, 146 kDa) is encoded by the human UBE4B gene. This protein plays a role in the mediation of polyubiquitination.;

NCIt note : Ubiquitin conjugation factor E4 B interacts with E3 ubiquitin-protein ligase Mdm2 to ubiquitinylate cellular tumor antigen p53. This targets cellular tumor antigen p53 to the proteasome for degradation. (Nature Medicine. 2011; DOI: 10.1038/nm.2283.);

Details

Origin ID

C95843;

UMLS CUI

C1176202;

OMIM relation
- Ubiquitination factor e4b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- UBE4B protein, human [MeSH Supplementary Concept]
- UBE4B protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- UBE4B Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Polyubiquitination [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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