Preferred Label : Bortezomib;
NCIt related terms : [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic
Acid; PS-341; velcade;
NCIt definition : A dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly
inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins.
By blocking the targeted proteolysis normally performed by the proteasome, bortezomib
disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis,
and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB,
a protein that is constitutively activated in some cancers, thereby interfering with
NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib
delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy.;
Alternative definition : NCI-GLOSS: A drug used to treat multiple myeloma. It is also used to treat mantle
cell lymphoma in patients who have already received at least one other type of treatment
and is being studied in the treatment of other types of cancer. Bortezomib blocks
several molecular pathways in a cell and may cause cancer cells to die. It is a type
of proteasome inhibitor and a type of dipeptidyl boronic acid.;
UNII : 69G8BD63PP;
InChIKey : GXJABQQUPOEUTA-RDJZCZTQSA-N;
CAS number : 179324-69-7;
Drug name : Velcade;
Molecule name : LDP 341; LDP-341; PS-341; MLN 341; PS 341; MLN-341;
Chemical formula : C19H25BN4O4;
NSC code : 681239;
ChEBI ID : CHEBI:52717;
Codes from synonyms : CDR0000413734; CDR0000046719; 31947; CDR0000269133; 75;
Origin ID : C1851;
UMLS CUI : C1176309;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
https://pgtmsite.files.wordpress.com/2024/01/bortezomib_protocolechumrevmcr_20150511.pdf
2015
Canada
drug information
Bortezomib
bortezomib
Bortezomib
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https://pgtmsite.files.wordpress.com/2024/01/bortezomib_myelomemultiple_pgtm_20050922.pdf
2005
Canada
drug information
bortezomib
Bortezomib
multiple myeloma
Multiple
NCI CTEP SDC Myeloma Sub-Category Terminology
multiple myeloma
Bortezomib
Myeloma
Multiple Myeloma
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