Transient Receptor Potential Cation Channel Subfamily V Member 6

Preferred Label : Transient Receptor Potential Cation Channel Subfamily V Member 6;

NCIt synonyms : Epithelial Calcium Channel 2; TrpV6; CaT-like; ECaC2; Calcium Transport Protein 1; CaT1; CaT-L;

NCIt related terms : transient receptor potential cation channel, subfamily V, member 6;

NCIt definition : Transient receptor potential cation channel subfamily V member 6 (725 aa, 83 kDa) is encoded by the human TRPV6 gene. This protein is involved in the mediation of calcium-dependent signaling that regulates both muscle contraction and neurotransmission.;

Alternative definition : NCI-GLOSS: A protein found in cell membranes that moves calcium into cells. Levels of transient receptor potential cation channel, subfamily V, member 6 are lower than normal in patients who don't have enough vitamin D. High levels of the protein may be found in breast cancer tissue. It is a type of calcium channel protein.;

Codes from synonyms : CDR0000655135; CDR0000655134;

Details

Origin ID

C94620;

UMLS CUI

C2986601;

OMIM relation
- Transient receptor potential cation channel, subfamily V, member 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ion Channel Protein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- TRPV6 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Gastrointestinal Tract [NCIt concept]
- Ion Channel [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ankyrin Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- PTPN1 Signaling Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Signaling [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Muscle Contraction [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
is_target
- FR Alpha/TRPV6 Bispecific Ligand Drug Conjugate CBP-1008 [NCIt concept]

Keyword's position in hierarchy(ies) :

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