Preferred Label : Bispecific Ligand-drug Conjugate CBP-1019;
NCIt synonyms : Bispecific Ligand/Topoisomerase Inhibitor Conjugate CBP-1019;
NCIt definition : A bispecific ligand-drug conjugate targeting two as of yet undisclosed receptors and
conjugated to a topoisomerase inhibitor, with potential antineoplastic activity. Upon
administration of bispecific ligand-drug conjugate CBP-1019, the bispecific ligand
moiety targets and binds to one or both of the two as of yet undisclosed receptors
expressed in certain tumor types. After internalization of the agent, the topoisomerase
inhibitor inhibits DNA topoisomerase activity, thereby inhibiting DNA replication
which results in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of cancer cells expressing the receptor(s).;
Molecule name : CBP 1019; CBP-1019;
NCI Metathesaurus CUI : CL1907552;
Origin ID : C200554;
concept_is_in_subset
