Folate Receptor Alpha

Preferred Label : Folate Receptor Alpha;

NCIt synonyms : FOLR1; Adult Folate-Binding Protein; FR-Alpha; Adult Folate Receptor; Ovarian Tumor-Associated Antigen MOv18; FOLR; FBP; MOv18; Folate-Binding Protein, Adult; Folate Receptor, Alpha; Folate Receptor 1; KB Cells FBP; Folate Receptor-1; FolRa;

NCIt definition : Folate receptor alpha (257 aa, 30 kDa) is encoded by the human FOLR1 gene. This protein is involved in cellular import of folate, 5-methyltetrahydrofolate, and folic acid derivatives.;

NCIt note : Folate receptor alpha has eight disulfide bonds and is attached to the cell membrane by a GPI-anchor.;

Details

Origin ID

C39284;

UMLS CUI

C1384573;

Currated CISMeF NLP mapping
- folate receptor 1 [MeSH Descriptor]
- folate receptor 1 [MeSH concept]
OMIM relation
- Folate receptor, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FOLR1 protein, human [MeSH concept]
- FOLR1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FOLR1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- MOv-PBL Vaccine [NCIt concept]
gene_product_expressed_in_tissue
- Epithelial Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Outer Leaflet of the Lipid Bilayer [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transmembrane Transport [NCIt concept]
is_target
- Anti-FOLR1 CoStAR-expressing Autologous Tumor-infiltrating Lymphocytes ITIL-306 [NCIt concept]
- Anti-FRa Antibody-drug Conjugate AZD5335 [NCIt concept]
- Anti-FRa/DM21 ADC IMGN151 [NCIt concept]
- Anti-FRalpha/Exatecan ADC PRO1184 [NCIt concept]
- Anti-folate Receptor Alpha Antibody-drug Conjugate AMT-151 [NCIt concept]
- FR Alpha/TRPV6 Bispecific Ligand Drug Conjugate CBP-1008 [NCIt concept]
- Farletuzumab [NCIt concept]
- Farletuzumab Ecteribulin [NCIt concept]
- Folate Binding Protein E39 Peptide Vaccine [NCIt concept]
- Folate Binding Protein J65 Peptide Vaccine [NCIt concept]
- Folate Receptor Targeted Epothilone BMS753493 [NCIt concept]
- Folate Receptor-Targeted Technetium Tc-99m EC20 [NCIt concept]
- Folate Receptor-Targeted Tubulysin Conjugate EC1456 [NCIt concept]
- Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225 [NCIt concept]
- Folate-FITC [NCIt concept]
- Luveltamab Tazevibulin [NCIt concept]
- MOv19 CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocytes [NCIt concept]
- Mirvetuximab Soravtansine [NCIt concept]
- Multi-epitope Anti-folate Receptor Peptide Vaccine TPIV 200 [NCIt concept]
- Multi-epitope Folate Receptor Alpha Peptide Vaccine [NCIt concept]
- Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine [NCIt concept]
- Pafolacianine [NCIt concept]
- Vintafolide [NCIt concept]

Keyword's position in hierarchy(ies) :

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