NCIt definition : A folate receptor-targeting antimitotic agent with potential antineoplastic activity.
Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked
to a single folate molecule. Mediated through the folate moiety, this agent delivers
the antimitotic epothilone component into cells expressing folic acid receptors, frequently
upregulated in many types of tumor cells. After ligand-receptor internalization, the
epothilone moiety induces microtubule polymerization and stabilizes microtubules against
depolymerization, resulting in the inhibition of mitosis and cellular proliferation.;
Semantic type(s)