" /> Pafolacianine - CISMeF





Preferred Label : Pafolacianine;

NCIt synonyms : Fluorescent Imaging Ligand OTL38;

NCIt definition : A fluorescent imaging agent composed of a folate receptor-alpha (FRa)-targeting ligand conjugated to a fluorescent near infrared (NIR) dye, that can be used for imaging of FRa-expressing tumor cells. Upon administration, the FRa-targeting moiety of pafolacianine specifically binds to FRa expressed on tumor cells thus selectively delivering the fluorescent dye to FRa-expressing tumor cells. Upon NIR imaging, tumor cells fluoresce, which allows for the visualization and identification of FRa-overexpressing tumor cells. FRa, a high-affinity folate-binding protein and a member of the folate receptor family, is overexpressed in various cancer cell types.;

UNII : F7BD3Z4X8L;

InChIKey : PDXNSXLPXJFETD-DYVQZXGMSA-N;

CAS number : 1628423-76-6;

Molecule name : OTL38;

NCI Metathesaurus CUI : CL1413250;

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Keyword's position in hierarchy(ies) : arborescence

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10/05/2025


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