NCIt definition : The sodium salt form of pafolacianine, a fluorescent imaging agent composed of a folate
receptor-alpha (FRa)-targeting ligand conjugated to a fluorescent near infrared (NIR)
dye, that can be used for imaging of FRa-expressing tumor cells. Upon administration,
the FRa-targeting moiety of pafolacianine specifically binds to FRa expressed on tumor
cells thus selectively delivering the fluorescent dye to FRa-expressing tumor cells.
Upon NIR imaging, tumor cells fluoresce, which allows for the visualization and identification
of FRa-overexpressing tumor cells. FRa, a high-affinity folate-binding protein and
a member of the folate receptor family, is overexpressed in various cancer cell types.;
Semantic type(s)